Volume 1 Supplement 1

BioSysBio 2007: Systems Biology, Bioinformatics, Synthetic Biology

• Poster presentation
• Open Access

Set theoretical and algebraic model for redundancies in the genetic code

BMC Systems Biology20071 (Suppl 1) :P34

https://doi.org/10.1186/1752-0509-1-S1-P34

• Published:

Keywords

• Codon
• Cellular Automaton
• Genetic Code
• Algebraic Model
• Bijective Mapping

Background

Codons are similar to syllogisms. Each codon has a complement – an anticodon – and syllogisms have such too. Another point is that codons and syllogisms consist of 3 of 4 possible building blocks. So 64 syllogisms should exist, but only 19 make sense. Each syllogism is a set operation, which I can represent with Shegalkin-Polynomials [1]. This needs a continuous view, which is ordinary in biological systems. It accrues matrices with special properties. They are self-similar, that means they can be generated with a tensor product of their own. Other methods work with power sets or multidimensional tetrahedral numbers. Because of these different generation methods it can be shown, that the matrices can be generated with a cellular automaton. Each cellular automaton is producible with a linear automaton [27], so there is an other aspect of dependence of the this model and decoding of amino acids. The decoding of amino acids follows the rules of a linear automaton. In order to combine the fields of syllogisms and amino acids a different representation for them is used – a tetrahedral grid. This is possible, because the number of syllogisms and amino acids is not only a square number, it is also a triangle number. Prof. Dr. Franke's matrices [8] let me construct such a grid, because of their structure of a Pascal triangle.

Results

My work shows the existence of bijective mappings between syllogisms and amino acids (see Figures 1 and 2). This is discernible with the tetrahedral grid. The smaller triangles in the grid can not be ordered arbitrarily without losing information. It follows because of triangle rotations. Nevertheless the triangles of redundant coded amino acids with degeneracy 6 (arginine, leucine and serine) seem to be ordered arbitrarily in the grid. Their distribution in the grid fits to model of family boxes [9, 10] and to a dynamical model by Magini and Hornos [11]. My model has some other similarities with the last one; for example a basic approach with a Platonic solid (tetrahedron and octahedron). Mathematical invalid syllogisms are very important in my model too, because in strong logics they do not work every time, but they are useful in biology.

Conclusion

The bijective mapping could explain Prof. Dr. Freeland's presumption [12], that fewer amino acids existed in the past. Mathematical invalid syllogisms are very interesting here. But the further work is also going to aim on a more intensive test of the position of the amino acids and syllogisms. The positions seem to have something in common with chemical properties. This would help to explain that amino acids, which drift from the genetic code, have similar chemical properties i.e. hydrophobia. Prof. Dr. Freeland wrote about this [12] too. Shegalkin-Polynomials shall be used here.

Authors’ Affiliations

(1)
University of Hamburg, Hamburg, Germany

References

1. Shegalkin II: Die Arithmetisierung der symbolischen Logik. Mat co. 1928, 311-377.Google Scholar
2. Wolfram S, Farmer JD, Toffoli T: Cellular Automata. Proceedings of an Interdisciplinary Workshop. Physica D. 1984, 10D (1 and 2):Google Scholar
3. Dewdney AK: The Planiverse. 1984, Poseidon PressGoogle Scholar
4. Hayes B: Tabellenkalkulation. Spektrum der Wissenschaft. 1988, 46-52. Sonderheft Computer-Kurzweil IIGoogle Scholar
5. Hayes B: Endliche Automaten. Spektrum der Wissenschaft. 1988, 53-59. Sonderheft Computer-Kurzweil IIGoogle Scholar
6. Hayes B: Zelluläre Automaten. Spektrum der Wissenschaft. 1988, 60-67. Sonderheft Computer-Kurzweil IIGoogle Scholar
7. Dewdney AK: Lineare Automaten. Spektrum der Wissenschaft. 1988, 68-73. Sonderheft Computer-Kurzweil IIGoogle Scholar
8. Franke D: Sequentielle Systeme. 1994, Vieweg Verlag
9. Osawa S, Jukes TH, Watanabe K, Muto A: Microbiol Rev. 1992, 56: 229-264.
10. Osawa S: Evolution of the Genetic Code. 1995, Oxford: Oxford University PressGoogle Scholar
11. Magini M, Hornos JEM: A Dynamical System for the Algebraic Approach to the Genetic Code. Brazilian Journal of Physics. 2003, 33 (4):Google Scholar
12. Freeland SJ, Hurst LD: Der raffinierte Code des Lebens. Spektrum der Wissenschaft. 2006, 18-25. Dossier Das neue GenomGoogle Scholar